How many muscles does it take to smile and to frown? July 8, 2020 by Pamela Landy Smiling is easier on the face than frowning. It takes 17 muscles to smile and 43 to frown. Related Answers How long has the Oberammergau Passion Play been staged? Which comes out of the door at the end of The Lady or the Tiger, the lady or the tiger? How old is The Tale of Genji? What is the opening line of Edward Albee’s play Who’s Afraid of Virginia Woolf (1962)? Who said, “When you call me madam, smile”? What movie introduced the line, “If you want to call me that, smile”?