Who invented the toothbrush? October 17, 2011 by Pamela Landy The first toothbrush with bristles was developed in China in 1498. Bristles were taken from hogs at first, and later from horses and even badgers. Not until 1938 were nylon bristles, more sanitary and less dangerous, developed by Du Pont. Related PostsWho invented the term Fifth Column?When was the chair invented?Who invented shrapnel?Who invented the rubber band?Who invented the brassiere?Who invented the air conditioner?