Who was the first female to hold a post in the U.S. Cabinet? March 19, 2012 by Pamela Landy · Filed Under: Firsts The first female to hold a post in the U.S. Cabinet was Frances Perkins. She served as Secretary of Labor under Franklin D. Roosevelt from 1933 to 1945. Related PostsWho was the first U.S. president to hold a press conference?What office did Harvey Milk hold?What poem contains the line, “Things fall apart; the center cannot hold”?Who were the members of President George Washington’s first cabinet?Who was the first U.S. president to have more than one woman in his cabinet?